Acetyl Hexapeptide-3 (Argireline) 200mg Research Peptide
Acetyl Hexapeptide-3 (Argireline) 200mg is a synthetic hexapeptide widely associated with the name Argireline. It is also commonly identified in modern cosmetic nomenclature as Acetyl Hexapeptide-8.
The naming history can create confusion when comparing chemical databases, supplier catalogs, and scientific publications. FDA-linked substance records identify Acetyl Hexapeptide-8 Amide and list Acetyl Hexapeptide-3 and Argireline among its synonyms.
The best-known structure is:
Ac-Glu-Glu-Met-Gln-Arg-Arg-NH₂
or, in abbreviated form:
Ac-EEMQRR-NH₂
Argireline is a short, synthetic peptide designed around a region of SNAP-25. This structural relationship is central to its research interest because SNAP-25 participates in the SNARE protein machinery responsible for vesicle docking and membrane fusion.
The 200mg product quantity provides researchers with a defined amount of material for laboratory investigation. Product-specific formulation, purity, analytical testing, and batch documentation should always be verified from the applicable product documentation.
Primary Research Classification
- Compound: Acetyl Hexapeptide-3 (Argireline)
- Common modern INCI name: Acetyl Hexapeptide-8
- Peptide class: Synthetic hexapeptide
- Research category: Cosmetic and molecular biology research peptide
- Primary research area: SNARE-mediated exocytosis
- Related protein: SNAP-25
- Sequence: Ac-Glu-Glu-Met-Gln-Arg-Arg-NH₂
- Short sequence: Ac-EEMQRR-NH₂
- CAS: 616204-22-9
- Approximate molecular weight: 889 g/mol
- Product quantity: 200mg
Public records are not completely consistent regarding the deposited chemical structure for CAS 616204-22-9. PubChem currently displays a record with a formula and molecular weight that differ from the conventional Ac-EEMQRR-NH₂ structure, while FDA-linked records confirm the Argireline/Acetyl Hexapeptide-8 identity and CAS number. For that reason, batch-specific documentation should take precedence when exact analytical identity is required.
Scientific Background
Argireline was developed as a synthetic peptide modeled on a portion of SNAP-25. SNAP-25 is a component of the neuronal SNARE machinery that helps coordinate calcium-dependent vesicle fusion.
SNARE proteins form a molecular complex that brings vesicle and cell membranes into close proximity. This process is essential for regulated exocytosis, including the release of neurotransmitters.
The scientific interest in Argireline comes from its ability to interact with this molecular system without functioning as an enzyme. Instead, the peptide has been investigated as a competitive or interfering peptide that can alter protein-complex formation or stability.
An early mechanistic study reported that Ac-EEMQRR-NH₂ interfered with formation or stability of the SNARE complex and reduced neurotransmitter release in experimental models.
This makes Acetyl Hexapeptide-3 (Argireline) particularly relevant to researchers studying short bioactive peptides, peptide–protein interactions, exocytosis, and neuromuscular signaling.
Mechanism of Research Interest
Argireline does not work through a conventional hormone receptor pathway. Its primary research interest instead involves protein–protein interactions associated with vesicle fusion.
The proposed mechanism can be summarized as follows:
- SNAP-25 participates in formation of the SNARE complex.
- The SNARE complex helps organize calcium-dependent vesicle fusion.
- Argireline is structurally related to a region of SNAP-25.
- Experimental research indicates that the peptide can interfere with SNARE complex formation or stability.
- This interference can reduce calcium-dependent neurotransmitter release in experimental systems.
This mechanism is fundamentally different from botulinum neurotoxins. Botulinum toxins are proteolytic enzymes that cleave SNARE proteins, whereas Argireline is a small peptide investigated for its ability to influence molecular interactions within the same broader exocytotic machinery.
That distinction is important when interpreting research literature and avoiding unsupported comparisons.
Key Research Applications
1. SNARE Complex Research
Argireline provides a useful model for studying the structural requirements of SNARE-mediated membrane fusion.
Researchers can investigate how short peptides interact with SNAP-25-related molecular regions and how those interactions influence protein-complex stability.
2. Neurotransmitter Release
Experimental studies have examined the effect of Argireline on calcium-dependent neurotransmitter release. These studies provide a basis for investigating exocytosis and neuromuscular signaling at the molecular level.
3. Peptide–Protein Interaction Studies
Because Argireline is derived from a protein-associated sequence, it can be useful in research examining:
- Peptide binding interactions
- Protein-complex assembly
- Molecular recognition
- Structural mimetic design
- Short-peptide structure–activity relationships
4. Cosmetic Peptide Research
Argireline has attracted significant interest in cosmetic science because its proposed mechanism involves molecular processes associated with facial muscle activity and expression-line formation.
Clinical and experimental studies have reported changes in wrinkle appearance following topical formulations containing Argireline. However, formulation composition, concentration, delivery system, study design, and other ingredients can influence observed outcomes.
A 2013 randomized placebo-controlled study evaluated Argireline in Chinese subjects, while other research has investigated acetyl hexapeptide-8 in combination with different cosmetic delivery systems.
More recent research has also examined multi-ingredient cosmetic formulations containing acetyl hexapeptide-8. Because such formulations contain multiple active ingredients, their findings should not automatically be attributed to Argireline alone.
Argireline and Skin Biology Research
Acetyl Hexapeptide-3 (Argireline) is particularly interesting in cosmetic peptide research because it represents a different approach from peptides that primarily target collagen synthesis or extracellular matrix remodeling.
Instead, Argireline research focuses on the relationship between:
SNAP-25 → SNARE complex → calcium-dependent exocytosis → neurotransmitter release → muscle-associated signaling
This makes the peptide useful for comparative studies involving other cosmetic peptides that target different molecular pathways.
Research has reported changes in wrinkle measurements in topical studies, but results from a finished cosmetic formulation cannot be assumed to represent the activity of isolated research-grade peptide material.
Technical Specifications
| Specification | Details |
|---|---|
| Product Name | Acetyl Hexapeptide-3 (Argireline) 200mg |
| Common Name | Argireline |
| Alternative Name | Acetyl Hexapeptide-8 |
| Classification | Synthetic hexapeptide |
| Sequence | Ac-Glu-Glu-Met-Gln-Arg-Arg-NH₂ |
| Short Sequence | Ac-EEMQRR-NH₂ |
| CAS Number | 616204-22-9 |
| Approx. Molecular Weight | ~889 g/mol |
| Primary Research Interest | SNARE/exocytosis and peptide–protein interactions |
| Related Protein | SNAP-25 |
| Product Quantity | 200mg |
Technical note: Public chemical databases contain discrepancies for this compound’s deposited structure. The conventional Argireline structure is Ac-EEMQRR-NH₂, while the current PubChem record for Acetyl Hexapeptide-3 reports a different calculated formula and molecular weight. FDA-linked substance records support the Argireline/Acetyl Hexapeptide-8 identity and CAS 616204-22-9.
Product-specific information should be verified from the applicable Certificate of Analysis or product documentation.
Storage and Handling
Storage conditions can depend on the specific product formulation, packaging, and batch documentation. No unsupported storage temperature or shelf-life claim should be assigned to this 200mg product.
Researchers should follow the handling and storage information supplied with the applicable batch.
Product-specific information should be verified from the applicable Certificate of Analysis or product documentation.
Why Researchers Choose Peptide Sciences
Researchers evaluating Peptide Sciences products should focus on documented product attributes rather than unsupported assumptions about a supplier or individual batch.
For Acetyl Hexapeptide-3 (Argireline), useful documentation may include:
- Confirmed peptide identity
- Batch-specific Certificate of Analysis
- Analytical characterization
- Purity information when documented
- HPLC or mass-spectrometry data when applicable
- Product-specific formulation information
- Lot and batch identification
Researchers searching for a peptide science coupon code should treat promotional information separately from scientific product validation. A coupon or discount does not establish peptide identity, purity, analytical quality, or suitability for a particular experiment.
Likewise, independent peptide science research should be based on primary literature and batch-specific documentation rather than marketing claims alone.
Research Evidence and Limitations
The scientific literature supports substantial interest in Argireline as a model peptide for studying neurotransmitter release, SNARE-related molecular interactions, and cosmetic applications. Early mechanistic work linked the peptide to interference with SNARE complex formation and calcium-dependent exocytosis.
Human studies have also investigated topical Argireline-containing preparations and reported improvements in wrinkle measurements.
However, these findings should be interpreted carefully.
Research involving finished cosmetic formulations may include additional ingredients, delivery systems, or formulation effects. Therefore, results from a multi-ingredient product cannot automatically be attributed to isolated Acetyl Hexapeptide-3.
Similarly, laboratory findings involving molecular interactions or cellular systems should not be interpreted as proof of clinical efficacy.
Researchers should evaluate experimental design, peptide identity, purity, formulation, concentration, controls, and analytical documentation when comparing results between studies.
Laboratory Research Use Only
Acetyl Hexapeptide-3 (Argireline) 200mg is presented for laboratory research use only. This product description is intended to support scientific investigation of peptide structure, peptide–protein interactions, SNARE biology, exocytosis, neurotransmitter-release pathways, and cosmetic peptide research.
It is not a recommendation for human or animal use and does not provide dosing, administration, treatment, or therapeutic instructions.
